SYNOPSIS Living culture forms of “ Leptomonas pessoai ” cross protected mice against T. cruzi challenge infection. Circulating antibodies have been detected in the immunized mice by immunodiffusion analysis, passive hemagglutination, complement fixation test and antibody binding assay; these antibodies cross reacted with T. cruzi extracts. A cellular immune response was indicated by leucocyte migration inhibition using L. pessoai and T. cruzi antigens, strongly suggesting a role for cell‐mediated immunity in the mechanism of protection induced by L. pessoai.
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Souza et al. (1974) studied this question.
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