Why the study?
Does myocardial strain analysis using SSFP cine MRI correlate with speckle-tracking echocardiography in patients with HFpEF?
Does myocardial strain analysis using SSFP cine MRI correlate with speckle-tracking echocardiography in patients with HFpEF?
Strain methods' interchangeability in HFpEF unestablished without results; leaves open need for direct validation studies.
Background Changes in myocardial strain parameters is of interest in patients with heart failure as an objective measure of disease severity. Speckle-tracking echocardiography (STecho) is the accepted standard of reference for myocardial strain analysis given superior temporal resolution; however, difficult acoustic windows and limited contrast to noise resolution can limit strain analysis. Preliminary work using deformation field analysis at steady state free precession (SSFP) cine MR imaging has shown that strain analysis at CMR is similar between conventional and highly accelerated GRAPPA cine acquisitions. The purpose of this study is to compare the strain values in patients with heart failure and preserved ejection fraction (HFpEF, left ventricular ejection fraction >50%) at SSFP cine MRI with ST-echo. Methods Retrospective analysis of Cardiac MR and echocardiographic images from 15 patients (5 men, avg age 61.2 yrs) with HFpEF. Cardiac MR images were obtained at 1.5 T (MAGNETOM Avanto, Siemens Medical Systems, Erlangen, AG) using GRAPPA factor 2 acceleration (temp res = 39.2 msec, spatial res = 1.5 × 1.5 mm, thickness = 6 mm). Myocardial strain analysis at Cardiac MR was performed using prototype software calculating Lagrangian strain from deformation field analysis (Siemens Corp, Corporate Technology, Princeton, NJ). Transthoracic echocardiography exams included apical 4-chamber and mid-ventricular short axis views. Left ventricular (LV) mid ventricular average and peak systolic radial and circumferential strains as well as longitudinal strain data was calculated. Peak and average right ventricular (RV) longitudinal strain was also obtained. CMR and ST-Echo derived strain indices were compared using the Pearson correlation. Inter and intraobserver variance was assessed for CMR-derived RV and LV longitudinal strain analysis using the intraclass correlation coefficient (ICC). Results
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Smith et al. (2014) studied this question.
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