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An investigation of the indole alkaloids of Haplophyton crooksii has resulted in the identification of two new alkaloids 10-methoxy- N1 -methylpericyclivine ( 1 ) and 16-decarbomethoxyvinervinine ( 2 ) and 13 known alkaloids crooksiine, yohimbine, β-yohimbine, crooksidine, decarbomethoxytetrahydrosecodine, akuammicine, tubotaiwine, lanceomigine, lanceomigine N -oxide, haplophytine, cimicine, cimicidine, and akuammidin as major alkaloids of this shrub. All of the isolated alkaloids showed an inhibition of acetylcholinesterase activity in vitro.
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Mroue et al. (1996) studied this question.
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