An Epac-selective precursor with high potency: Signalling by the second messenger cAMP is mediated by its receptor proteins protein kinase A (PKA), Epac and cyclic-nucleotide-regulated ion channels. This manuscript describes the synthesis and biological characterisation of a precursor that selectively activates Epac and that is 100 to 1000 times more efficient under biological conditions than the parental compound.
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Vliem et al. (2008) studied this question.
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