Key result
A heart V10 greater than 72.8% was a strong independent predictive factor for the development of pericardial effusion in patients with oesophageal cancer treated with chemoradiotherapy (OR 12.2).
Why the study?
Do heart dose-volume histogram parameters predict the development of pericardial effusion in patients with oesophageal cancer treated with chemoradiotherapy?
Observational (n=143)
No
Do heart dose-volume histogram parameters predict the development of pericardial effusion in patients with oesophageal cancer treated with chemoradiotherapy?
Heart dose-volume histogram parameters, specifically a V10 > 72.8%, are strong independent predictors for the development of pericardial effusion in esophageal cancer patients treated with chemoradiotherapy.
Heart V10 >72.8% may flag high-risk patients; leaves open whether constraints reduce effusion incidence.
OBJECTIVE: To identify predictive factors for the development of pericardial effusion (PCE) in patients with oesophageal cancer treated with chemotherapy and radiotherapy (RT). METHODS: From March 2006 to November 2012, patients with oesophageal cancer treated with chemoradiotherapy (CRT) using the following criteria were evaluated: radiation dose >50 Gy; heart included in the radiation field; dose-volume histogram (DVH) data available for analysis; no previous thoracic surgery; and no PCE before treatment. The diagnosis of PCE was independently determined by two radiologists. Clinical factors, the percentage of heart volume receiving >5-60 Gy in increments of 5 Gy (V5-60, respectively), maximum heart dose and mean heart dose were analysed. RESULTS: A total of 143 patients with oesophageal cancer were reviewed retrospectively. The median follow-up by CT was 15 months (range, 2.1-72.6 months) after RT. PCE developed in 55 patients (38.5%) after RT, and the median time to develop PCE was 3.5 months (range, 0.2-9.9 months). On univariate analysis, DVH parameters except for V60 were significantly associated with the development of PCE (p < 0.001). No clinical factor was significantly related to the development of PCE. Recursive partitioning analysis including all DVH parameters as variables showed a V10 cut-off value of 72.8% to be the most influential factor. CONCLUSION: The present results showed that DVH parameters are strong independent predictive factors for the development of PCE in patients with oesophageal cancer treated with CRT. ADVANCES IN KNOWLEDGE: A heart dosage was associated with the development of PCE with radiation and without prophylactic nodal irradiation.
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Hayashi et al. (2014) conducted an observational in Oesophageal cancer (n=143). Heart V10 > 72.8% vs. Heart V10 ≤ 72.8% was evaluated on Development of pericardial effusion (PCE) (OR 12.2, 95% CI 5.5-27.4, p=<0.001). A heart V10 greater than 72.8% was a strong independent predictive factor for the development of pericardial effusion in patients with oesophageal cancer treated with chemoradiotherapy (OR 12.2).
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