Answers are grounded in this paper and cite their sources.
The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % of Pd(OAc)2, 10-20 mol % of DMSO, and 4-11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.
No takes yet. Share an insight, caveat, or question.
Brasche et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: