Haptoglobin Polymorphism and Hyperuricemia among Stroke Patients

Background and Objectives: Stroke is a major public health problem in our regions. In classical risk factors, differences in genetic susceptibility have been reported. So, our study aims to study the polymorphism of the haptoglobin gene as a factor predisposing to the onset of stroke and secondly to evaluate hyperuricemia as an associated risk factor. This is a longitudinal study and control cases. Materials and Methods: The number of subjects included was 46 stroke patients and 46 controls matched by sex and age2 years. The parameters studied were genotyping of the Hp gene and uricemia in all subjects included. Results: The mean age of our patients was 63.3714 years with a sex ratio of 0.70. Ischemic stroke was more represented in our population with a rate of 60.87%. The Hp2-2 genotype was significantly more common in subjects with stroke (36.96%) compared to control subjects (17.39%) and a statistically significant difference was found with p = 0.002. The mean serum uterine was 64.81 g LG 1 in stroke and the values were increased more in patients than in controls (p<0.0001). The frequency of hyperuricemia was higher in stroke subjects with genotypes Hp2-2 with a rate of 46.66% against 33.33% for subjects of genotype Hp1-1. Conclusion: Our results show that Hp polymorphism and hyperuricemia play a role in the pathogenesis of stroke. However, the impact of these two parameters must be estimated in conjunction with the other genetic, biochemical and associated clinical risk factors.