The Quality of Life During Intravesical Bacillus Calmette-Guerin Therapy

No AccessJournal of UrologyClinical Urology: Original Article1 Apr 1996The Quality of Life During Intravesical Bacillus Calmette-Guerin Therapy Andreas Bohle, Friedrich Balck, Jorn Von Wietersheim, and Dieter Jocham Andreas BohleAndreas Bohle , Friedrich BalckFriedrich Balck , Jorn Von WietersheimJorn Von Wietersheim , and Dieter JochamDieter Jocham View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66224-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In the treatment of cancer the subjective evaluation of therapy induced side effects and quality of life must be considered. Adjuvant intravesical bacillus Calmette-Guerin (BCG) immunotherapy is regarded as highly effective but associated with significant side effects. To clarify whether these side effects significantly impact on patient satisfaction with life, a prospective survey of the health related quality of life and side effects was performed during an intravesical BCG treatment course. Materials and Methods: Symptoms and side effects were recorded daily during the 6-week instillation period in 30 patients. The quality of life was determined before, during and after intravesical therapy with the assistance of a self-reported questionnaire. Results: Due to a detailed subjective assessment of side effects, the course of local symptoms could be characterized with great reliability. Although side effects occurred, satisfaction with life in the patients studied was high and was not impaired during the treatment. The incidence of side effects correlated well with patient subjective evaluation of quality of life. Conclusions: Assessment of side effects and quality of life, as presented in this pilot study, can assist in the quantification of localized symptoms in intravesical therapy and could contribute to the comparability of clinical studies. With regard to intravesical BCG immunotherapy, our results suggest that the specific side effects do not seriously impair satisfaction with life in these patients. References 1 : SWOG 8795: a randomized comparison of bacillus Calmette-Guerin and mitomycin C prophylaxis in stage Ta and T1 transitional cell carcinoma of the bladder. J. Urol., part 21993; 149: 282A. abstract 275. Google Scholar 2 : Carcinoma in situ. Urol. Clin. N. Amer.1992; 19: 499. Google Scholar 3 : Long-term results of intravesical therapy for superficial bladder cancer. Urol. Clin. N. Amer.1992; 19: 573. Crossref, Medline, Google Scholar 4 : Local immune responses after intravesical BCG treatment of carcinoma in situ. Brit. J. Urol.1987; 60: 543. Google Scholar 5 : Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall. J. Urol.1992; 147: 1636. Link, Google Scholar 6 : Elevations of cytokines interleukin-1, interleukin-2 and tumor necrosis factor in the urine of patients after intravesical bacillus Calmette-Guerin immunotherapy. J. Urol.1990; 144: 59. Abstract, Google Scholar 7 : Effects of local bacillus Calmette-Guerin therapy in patients with bladder carcinoma on immunocompetent cells of the bladder wall. J. Urol.1990; 144: 53. Link, Google Scholar 8 : Complications of bacillus Calmette-Guerin immunotherapy. Urol. Clin. N. Amer.1992; 19: 565. Crossref, Medline, Google Scholar 9 : Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer. J. Urol.1986; 135: 272. Link, Google Scholar 10 : Psychometrische Testung der Munchner Lebensqualitats Dimensionen Liste (MLDL). In: Lebensqualitat bei kardiovaskularen Erkrankungen.. Edited by . Gottingen: Hogrefe1991: 73. Google Scholar 11 : Forschungsinstrumente zur Erfassung der Lebensqualitat bei Krebs--ein Uberblick. In: Jahrbuch der medizinischen Psychologie III. Psychosoziale Onkologie. Edited by . Berlin: Springer Verlag1989: 45. Google Scholar 12 : A modular approach to quality-of-life assessment in cancer clinical trials. In: Cancer Clinical Trials: A Critical Appraisal.. Edited by . Berlin: Springer Verlag1988: 231. Google Scholar 13 : Bacillus Calmette-Guerin treatment and vesicorenal reflux. Eur. Urol.1990; 17: 125. Google Scholar 14 : Lebensqualitat in der BRD. Objektive Lebensbedingungen und subjektives Wohlbefinden. Frankfurt/Main: Campus Verlag1984. Google Scholar 15 : Quality of life in patients with muscle-infiltrating bladder cancer and hormone-resistant prostatic cancer. Eur. Urol.1989; 16: 335. Google Scholar 16 : A modular approach to quality-of-life assessment in cancer clinical trials. Recent Results Cancer Res.1988; 111: 231. Crossref, Medline, Google Scholar 17 : Psychosocial adjustment and general state of health in patients with ileal conduit urinary diversion. Scand. J. Urol. Nephrol.1992; 26: 139. Google Scholar 18 : Assessment of quality of life in long-term survivors treated by first-line intravenous cisplatin for invasive bladder cancer. Prog. Clin. Biol. Res.1988; 260: 625. Google Scholar 19 : Quality of life after cystectomy. Comparison between patients with conduit and those with continent caecal reservoir urinary diversion. Brit. J. Urol.1988; 62: 240. Google Scholar 20 : Quality of life assessment in bladder cancer clinical trials: conceptual, methodological and practical issues. Prog. Clin. Biol. Res.1986; 221: 149. Google Scholar 21 : Quality of life and points in cancer clinical trials: review and recommendations. J. Natl. Cancer Inst.1989; 81: 485. Google Scholar 22 : A randomised prospective study comparing intravesical instillations of mitomycin-C, BCG-Tice, and BCG-RIVM in pTa-pT1 tumours and primary carcinoma in situ of the urinary bladder. Dutch South-East Cooperative Urological Group. Eur. J. Cancer1993; 29A: 1672. Crossref, Medline, Google Scholar 23 : The influence of symptoms of disease and side effects of treatment on compliance with cancer therapy. J. Clin. Oncol.1988; 6: 1746. Google Scholar 24 : Assessing the quality of life of cancer patients: practical issues in study implementation. J. Psychosoc. Oncol.1989; 7: 59. Google Scholar Departments of Urology and Psychosomatic Medicine and Psychotherapy, Medical University of Lubeck, Lubeck, Germany© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byHendricksen K, Cornel E, de Reijke T, Arentsen H, Chawla S and Witjes J (2012) Phase 2 Study of Adjuvant Intravesical Instillations of Apaziquone for High Risk Nonmuscle Invasive Bladder CancerJournal of Urology, VOL. 187, NO. 4, (1195-1199), Online publication date: 1-Apr-2012.PARKINSON J and KONETY B (2018) HEALTH RELATED QUALITY OF LIFE ASSESSMENTS FOR PATIENTS WITH BLADDER CANCERJournal of Urology, VOL. 172, NO. 6 Part 1, (2130-2136), Online publication date: 1-Dec-2004.BÖHLE A, JOCHAM D and BOCK P (2018) Intravesical Bacillus Calmette-Guerin Versus Mitomycin C For Superficial Bladder Cancer: A Formal Meta-Analysis of Comparative Studies on Recurrence and ToxicityJournal of Urology, VOL. 169, NO. 1, (90-95), Online publication date: 1-Jan-2003.MORALES A, CHIN J and RAMSEY E (2018) MYCOBACTERIAL CELL WALL EXTRACT FOR TREATMENT OF CARCINOMA IN SITU OF THE BLADDERJournal of Urology, VOL. 166, NO. 5, (1633-1638), Online publication date: 1-Nov-2001.GUNTHER J, FRAMBACH M, DEINERT I, BRANDAU S, JOCHAM D and BOHLE A (2018) EFFECTS OF ACETYLIC SALICYLIC ACID AND PENTOXIFYLLINE ON THE EFFICACY OF INTRAVESICAL BCG THERAPY IN ORTHOTOPIC MURINE BLADDER CANCER (MB49)Journal of Urology, VOL. 161, NO. 5, (1702-1706), Online publication date: 1-May-1999.Schatzl G, Madersbacher S, Lang T and Marberger M (2018) The Early Postoperative Morbidity of Transurethral Resection of the Prostate and oF 4 Minimally Invasive Treatment AlternativesJournal of Urology, VOL. 158, NO. 1, (105-111), Online publication date: 1-Jul-1997. Volume 155Issue 4April 1996Page: 1221-1226 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.Metrics Author Information Andreas Bohle More articles by this author Friedrich Balck More articles by this author Jorn Von Wietersheim More articles by this author Dieter Jocham More articles by this author Expand All Advertisement PDF downloadLoading ...