Key result
In patients with type 2 diabetes mellitus, 25(OH)D levels were significantly lower in those with orthostatic hypotension compared to those without (median 13 vs 17 ng/ml, p=0.026), though it was not an independent predictor.
Why the study?
Vitamin D deficiency is common in diabetic patients and can lead to neuropathy, prompting evaluation of the relationship between 25-hydroxyvitamin D levels and orthostatic hypotension.
Is there a relationship between 25-hydroxyvitamin D levels and the presence of orthostatic hypotension in pre-geriatric patients with uncontrolled Type 2 diabetes mellitus?
Cross-Sectional (n=118)
No
Is there a relationship between 25-hydroxyvitamin D levels and the presence of orthostatic hypotension in pre-geriatric patients with uncontrolled Type 2 diabetes mellitus?
In pre-geriatric patients with uncontrolled type 2 diabetes, vitamin D levels are significantly lower in those with orthostatic hypotension, though vitamin D deficiency is not an independent predictor of the condition.
Answers are grounded in this paper and cite their sources.
Lower 25(OH)D associates with orthostatic hypotension in T2DM but is not independent; hypothesis-generating and should not yet change practice.
Objective: Vitamin D deficiency is common in diabetic patients, and studies showed that it could lead to neuropathy. Therefore, we aimed to determine relationship between 25-hydroxyvitamin D (25(OH)D) levels and orthostatic hypotension (OH) which is a component of autonomic neuropathy in diabetic patients.Materials and Methods: A total of 118 patients with Type 2 diabetes mellitus and aged 50-65 years were included. Patients were divided into two groups as OH present and OH not present. 25(OH)D and other variable parameters were evaluated between these two groups.Results: A total of 118 patients, 66 female and 52 male, were included in this cross-sectional study. The mean age of the patients was 56.2±3.2 years. 25(OH)D levels were found to be significantly lower in the group with OH (p<0.026). Age and sex-adjusted regression analysis were performed to examine the relationship between 25(OH)D level and OH. It was found that 25(OH)D didn’t predict the presence of OH in the univariate and multivariate analyses (p >0.05).Conclusion: 25(OH)D levels are significantly lower in diabetic patients with OH. Although an independent relationship between them has not been demonstrated, it can be thought that correcting Vitamin D deficiency will be beneficial in the treatment of OH.
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YİĞİT et al. (2022) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=118). Orthostatic hypotension vs. No orthostatic hypotension was evaluated on 25(OH)D levels (median ng/ml) (p=0.026). In patients with type 2 diabetes mellitus, 25(OH)D levels were significantly lower in those with orthostatic hypotension compared to those without (median 13 vs 17 ng/ml, p=0.026), though it was not an independent predictor.
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