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Five patients with thrombocythemia are described. All were successfully treated with uracil mustard including two who were resistant to busulphan or radioactive phosphorus. Uracil mustard reduced the platelet count quickly and a single course of the drug produced a satisfactory remission without undue marrow depression. The results are compared with those which have been obtained with busulphan and radioactive phosphorus. It is concluded that uracil mustard may prove to be the most effective, convenient and possibly the safest, means of treating thrombocythemia.
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J. H. Robertson (1970) studied this question.
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