The evolving picture of the glioblastoma genome

Copyright: C 2010 Parsons et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Survival rates for patients with glioblastoma multiforme (GBM), the most common malignant brain tumor, remain dismal despite decades of basic and clinical research. New treatment strategies are desperately needed. Consequently, the high-throughput genomic technologies developed to facilitate examination of cancer genomes have recently been focused on GBM, with goals of identifying novel molecular targets and developing a clinically-relevant biological classification of this deadly cancer. These genomic analyses have provided an unprecedented view of the complex genetic landscape of GBM, confirming the central role of both wellestablished