Reconstitution of Mfn2 in diabetic hearts inhibited mitochondrial fission, improved mitochondrial function, and prevented the progression of diabetic cardiomyopathy.
Does targeting mitochondrial dynamics by regulating Mfn2 prevent or treat diabetic cardiomyopathy?
Regulating Mfn2 to target mitochondrial dynamics represents a potential novel therapeutic strategy for diabetic cardiomyopathy.
: Our study provides the first evidence that imbalanced mitochondrial dynamics induced by down-regulated Mfn2 contributes to the development of DCM. Targeting mitochondrial dynamics by regulating Mfn2 might be a potential therapeutic strategy for DCM.
Hu et al. (Tue,) conducted a other in Diabetic cardiomyopathy. Mfn2 reconstitution (Ad-Mfn2) vs. Empty adenoviral vectors (Ad-EV) was evaluated on Mitochondrial fission and cardiac function. Reconstitution of Mfn2 in diabetic hearts inhibited mitochondrial fission, improved mitochondrial function, and prevented the progression of diabetic cardiomyopathy.