Key result
Cigarette smoke exposure significantly increased right ventricular hypertrophy in A/J and A/HeJ mice, but susceptibility did not correlate with alveolar destruction.
Why the study?
Does cigarette smoke exposure induce cor pulmonale and is it directly related to alveolar destruction in inbred mice?
Population
Eight inbred strains of mice: 129XI/SvJ, A/J, A/HeJ, BALB/cJ, C3H/HeJ, C57BL/6J, DBA/2J, and SWR/J
Comparison
Mainstream cigarette smoke at a concentration of… vs Filtered air
Design
Preclinical
Follow-up
9 months
Authors
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Alveolar destruction may not drive smoke-induced RV hypertrophy in mice; leaves open cor pulmonale mechanisms and human relevance.
Does cigarette smoke exposure induce cor pulmonale and is it directly related to alveolar destruction in inbred mice?
Alveolar destruction by itself is not sufficient to cause smoking-induced cor pulmonale in inbred mice.
Nadziejko et al. (2007) studied Smoking-induced cor pulmonale and alveolar destruction. Mainstream cigarette smoke vs. Filtered air was evaluated on Right ventricular hypertrophy assessed by RV/(LV + S) ratio and alveolar destruction assessed by mean linear intercept. Cigarette smoke exposure significantly increased right ventricular hypertrophy in A/J and A/HeJ mice, but susceptibility did not correlate with alveolar destruction.
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