A number of new 3-(indazol-3 and 5-yl)-4(3H)-quinazolinone and 4(3H)-benzotriazinone derivatives were prepared by reaction of 3-or 5-(2-aminobenzamido)indazole with ethyl orthoesters and nitrous acid respectively.Structures were established on the basis of analytical and spectroscopic data.Single-crystal X-ray analysis confirmed the quinazolinone structure of compounds (5).The 4(3H)-quinazolinones and 4(3H)-benzotriazinones were tested at 200 pglml for antimicrobial activity against C. albicans, C. tropicalis and S. aureus, at 100 pM for their antitumor effect on human-lymphoblast-like cells and finally at 500 vM for 3a-hydroxysteroid dehydrogenase (3a-HSD) inhibition.Quinazolin-4(3/-/)-ones and benzotriazin-4(3H)-ones bearing a heferocyclic nucleus at the N-3 position have attracted an attention as sources for new biologically active agents which are associated with a wide range of pharmaceutical properties such as analgesic, antiinflammatory,
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Daidone et al. (1996) studied this question.