Key result
Helicobacter pylori CagA seropositivity was associated with a higher prevalence of atrial fibrillation, as well as significantly increased atrial dimension and C-reactive protein levels.
Why the study?
Does Helicobacter pylori CagA infection increase the risk of atrial fibrillation in patients with coronary artery disease?
Observational (n=265)
Does Helicobacter pylori CagA infection increase the risk of atrial fibrillation in patients with coronary artery disease?
Helicobacter pylori CagA infection is associated with an increased prevalence of atrial fibrillation, larger atrial size, and higher CRP levels in patients with coronary artery disease.
BACKGROUND: Helicobacter pyloriCagA strains could increase the risk for atrial fibrillation in patients with coronary artery disease METHODS: Serological status for H. pyloriCagA using enzyme-linked immunosorbent assay, C-reactive protein, total leucocytic count and atrial size were determined in 185 coronary artery disease patients (with and without atrial fibrillation) and 80 healthy subjects (control). RESULTS: CagA strain showed a higher prevalence in the atrial fibrillation group. Atrial dimension and C-reactive protein (independent predictors of atrial fibrillation) were significantly increased in the CagA seropositive subgroup CONCLUSIONS: There is a strong liaison between H. pylori CagA infection and atrial fibrillation in coronary artery disease. Increased C reactive protein and atrial size in atrial fibrillation patients may reflect atrial inflammatory remodeling.
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Badran et al. (2007) conducted an observational in Coronary artery disease and atrial fibrillation (n=265). Helicobacter pylori CagA seropositivity vs. Helicobacter pylori CagA seronegativity was evaluated on Prevalence of atrial fibrillation, atrial dimension, and C-reactive protein levels. Helicobacter pylori CagA seropositivity was associated with a higher prevalence of atrial fibrillation, as well as significantly increased atrial dimension and C-reactive protein levels.
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