Population
62 childhood adrenocortical tumor (ACT) patients
Design
Cohort
Authors
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CTNNB1 mutations were associated with mortality in childhood ACT; supports Wnt/β-catenin deregulation in tumorigenesis but leaves therapeutic implications open.
While CTNNB1 mutations are rare in childhood adrenocortical tumors, they are associated with poor prognosis, and widespread deregulation of the Wnt/β-catenin pathway suggests its involvement in tumorigenesis.
Leal et al. (2011) studied this question.
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