Key result
In Japanese patients with COPD, the cross-sectional area of the pectoralis muscles was significantly correlated with oxygen uptake at peak exercise after adjustment for age and FEV1 (β 0.175).
Why the study?
Decreased exercise tolerance is linked to poor prognosis in COPD, but the correlation between exercise tolerance and clinical parameters, particularly skeletal muscle cross-sectional area, needed clarification.
Cross-Sectional (n=69)
No
Effect estimate: β 0.175 (95% CI 0.03-0.319)
p-value: p=0.02
In Japanese patients with COPD, skeletal muscle cross-sectional area is significantly, albeit weakly, correlated with exercise tolerance as measured by peak oxygen uptake during cardiopulmonary exercise testing.
May inform exercise capacity assessment in COPD; hypothesis-generating for muscle-targeted interventions.
Decreasing exercise tolerance is one of the key features related to a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cardiopulmonary exercise testing (CPET) is useful for evaluating exercise tolerance. The present study was performed to clarify the correlation between exercise tolerance and clinical parameters, focusing especially on the cross-sectional area (CSA) of skeletal muscle. The present study investigated 69 patients with COPD who underwent CPET. The correlations between oxygen uptake ( V̇ O₂ V ˙ O 2 ) at peak exercise and clinical parameters of COPD, including skeletal muscle area measured using single-section axial computed tomography (CT), were evaluated. The COPD assessment test score (ρ = − 0.35, p = 0.02) was weakly correlated with V̇ O₂ V ˙ O 2 at peak exercise. In addition, forced expiratory volume in one second (FEV 1 ) (ρ = 0.39, p = 0.0009), FEV 1 /forced vital capacity (ρ = 0.33, p = 0.006), and the CSA of the pectoralis muscles (PMs) (ρ = 0.36, p = 0.007) and erector spinae muscles (ECMs) (ρ = 0.39, p = 0.003) were correlated with V̇ O₂ V ˙ O 2 at peak exercise. Multivariate analysis adjusted by age and FEV 1 indicated that PM CSA was weakly correlated after adjustment (β value [95% confidence interval] 0.175 [0.03–0.319], p = 0.02). In addition, ECM CSA tended to be correlated, but not significantly after adjustment (0.192 [− 0.001–0.385] p = 0.052). The COPD assessment test, FEV 1 , FEV 1 /FVC, PM CSA , and ECM CSA were significantly correlated with V̇ O₂ V ˙ O 2 at peak exercise.
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Tashiro et al. (2021) conducted a cross-sectional in Chronic obstructive pulmonary disease (COPD) (n=69). Skeletal muscle cross-sectional area (PMCSA and ECMCSA) was evaluated on Correlation between oxygen uptake (˙VO2) at peak exercise and cross-sectional area of pectoralis muscles (PMCSA) adjusted for age and FEV1 (β 0.175, 95% CI 0.03-0.319, p=0.02). In Japanese patients with COPD, the cross-sectional area of the pectoralis muscles was significantly correlated with oxygen uptake at peak exercise after adjustment for age and FEV1 (β 0.175).
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