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After a few years of the widespread and successful use of the sulfonamides in the treatment of acute gonorrhea, it was recognized by many observers that an increasing proportion of cases failed to respond to these drugs. Thus, during the year 1941, the late Oscar F. Cox1 obtained unquestionable sulfonamide cures in 70 per cent of all male patients admitted to the Boston Dispensary with active gonococcal infections, whereas of similar cases admitted during 1944, clean-cut sulfonamide cures occurred in only 28 per cent, a complete reversal of the 1941 figure. Laboratory data in these cases indicated that the failures . . .
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Hughes et al. (1948) studied this question.
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