Simultaneous occurrence of insulin allergy and immunologic insulin resistance has been reported in a few cases (1). A 62-year-old man with type 2 diabetes, who had been treated with insulin (premixed insulin of 30% aspart and 70% protaminated insulin aspart) for 3 months, noticed urticariform erythema and induration of the skin at the insulin-injection site. Erythema appeared immediately after the injection of insulin and disappeared after ∼20 min, while induration persisted for 3–4 days. HbA1c rose from 8.0 …
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Mizuhashi et al. (2006) studied this question.
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