Key result
Elevated Brain Natriuretic Peptide (BNP) was significantly associated with poor prognosis in patients with acute ischemic stroke (mean 667.06 vs 259.75, p=0.001), whereas CK-MB and Troponin I were not.
Why the study?
Are cardiac biomarkers (creatine kinase-MB, troponin I, and BNP) useful prognostic factors in patients with acute ischemic stroke?
Observational (n=219)
No
Are cardiac biomarkers (creatine kinase-MB, troponin I, and BNP) useful prognostic factors in patients with acute ischemic stroke?
Should not yet change practice in acute ischemic stroke; hypothesis-generating for BNP as prognostic marker.
Background: Cardiac enzymes such as creatine kinase-MB, troponin I, and brain natriuretic peptide (BNP) are thought to be useful prognostic factors in patients with acute ischemic stroke. This study investigated the efficacy of cardiac biomarkers as prognostic factors. Methods: We reviewed patients with acute ischemic stroke whose cardiac biomarkers had been measured and who were admitted to our hospital between January 2012 and December 2013. The cardiac biomarkers were measured within 24 hours after admission to the emergency room. We evaluated the clinical characteristics and compared the outcomes of the patients based on their cardiac biomarkers.
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Park et al. (2015) conducted an observational in Acute ischemic stroke (n=219). Elevated Brain Natriuretic Peptide (BNP) vs. Normal BNP levels was evaluated on Prognosis based on NIHSS change (deterioration/death vs improved/stationary) (p=0.001). Elevated Brain Natriuretic Peptide (BNP) was significantly associated with poor prognosis in patients with acute ischemic stroke (mean 667.06 vs 259.75, p=0.001), whereas CK-MB and Troponin I were not.
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