SUMMARY The thickness of the forearm skin and its collagen content and density were measured in a group of patients with acromegaly and hypopituitarism. In acromegaly the total content, thickness and collagen density were all increased. There was a smaller and less consistent increase in percentage collagen content. In hypopituitarism total skin collagen and thickness were both decreased and collagen density and percentage collagen content remained normal.
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Black et al. (1972) studied this question.
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