Iron deficiency in JAK2 exon12 and JAK2-V617F mutated polycythemia vera

Somatic driver mutations in JAK2 ( JAK2 V617F and exon 12 mutations) are detected >95% of persons with polycythemia vera (PV) [ 1 , 2 , 3 , 4 ]. Iron deficiency is universal in persons with PV at diagnosis and can be worsened by phlebotomy [ 5 ]. Precise mechanisms of iron deficiency in persons with PV at diagnosis are unknown. A previous study reported heterogeneous bone marrow expression of erythroferrone (ERFE) and hepcidin, important regulators of iron metabolism, in mice with JAK2 V617F or JAK2 exon12 mutation [ 6 ].