Cu-Catalyzed Radical Cascade Annulations of Alkyne-Tethered N-Alkoxyamides with Air: Facile Access to Isoxazolidine/1,2-Oxazinane-Fused Isoquinolin-1(2H)-ones

A series of structurally important isoxazolidine/1,2-oxazinane-fused isoquinolin-1(2 H )-ones have been facilely synthesized via efficient Cu-catalyzed aerobic oxidative radical cascade annulations of alkyne-tethered N -alkoxyamides. This method features air as the environment-friendly oxidant and has the merits of a cheap catalyst, broad substrates scope, high atom economy, and simple operation.