Renal and Circulatory Factors in the Edema Formation of Congestive Heart Failure 1
View Full Paper
Ask AI
Bookmark
Share
Population
39 cardiac patients (21 in uncompensated heart failure, 18 compensated cardiacs; 10 studied in both states).
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
Supports reevaluation of HF edema beyond GFR; leaves open whether targeting venous oxygenation or tubular function improves outcomes.
Structured PICO
P
Population
39 cardiac patients (21 in uncompensated heart failure, 18 compensated cardiacs; 10 studied in both states).
C
Comparator
Compensated cardiac state (either different patients or the same patients after compensation was restored).
O
Outcome
Renal and circulatory hemodynamics including filtration rate, sodium clearance, thiocyanate space, blood volume, cardiac output, and venous oxygen saturation.surrogate
Edema formation in congestive heart failure is closely associated with reduced mixed venous oxygen tension and impaired tubular sodium resorption, rather than solely a decrease in glomerular filtration rate.
Limitations
- Large standard errors due to natural variability of the data
- Presence of inanition on entrance played a complicating role in blood volume changes
- Incomplete mixing may have contributed to high venous oxygen content in some cases where samples were obtained from the right atrium
Cite This Study
Briggs et al. (1948) studied this question.
View Full Paper
Ask AI
Bookmark
Share