Case series reports breakthrough Candida tropicalis fungemia in stem cell recipients on caspofungin, highlighting resistance linked to Fks1p mutations.
We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.
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García‐Effrón et al. (2008) studied this question.
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