Key result
Exclusive breastfeeding during the first 6 months of life was associated with a twofold higher odds of seropositivity to poliovirus serotype 3 (OR 2.0) in children who received at least 5 doses of oral polio vaccine.
Cross-Sectional (n=365)
Yes
Odds Ratio: 2 (95% CI 1.1–3.6)
Absolute Event Rate: 81.3% vs 68.9%
p-value: p=0.025
Despite receiving at least 5 doses of oral polio vaccine, children in border regions of Iran showed suboptimal seroprotection against poliovirus serotype 3, highlighting a risk for polio reintroduction.
Exclusive breastfeeding was associated with higher poliovirus seropositivity; leaves open causal effects on vaccine response and polio risk in border regions.
Movements of populations from countries where polio has not been eradicated is a concern in the Islamic Republic of Iran. A cross-sectional, community-based study was implemented in 2010 in 2 districts in Sistan-va-Baluchestan Province near the south-east border. The aim was to determine the seroprevalence of antibodies in children aged 20 (± 2) months who had received at least 5 doses of trivalent oral polio vaccine. Using cluster sampling, 365 children were enrolled for serological testing. Antibody titres ≥ 1:10 were considered positive. Seropositive rates for antibody against poliovirus serotypes 1, 2 and 3 were 94.1%, 96.7% and 78.3% respectively. The lowest seropositive rate was for antibody against polio serotype 3 (PV3) among boys (58.3%). Exclusive breastfeeding showed a direct relationship with antibody response to PV3 (OR = 2.0; 95% CI: 1.1-3.6). Improving community protection against PV3 is an urgent programme priority.
No takes yet. Share an insight, caveat, or question.
Izadi et al. (2014) conducted a cross-sectional in Poliovirus immunity (n=365). Exclusive breastfeeding vs. Other feeding methods was evaluated on Seropositivity for antibody against poliovirus serotype 3 (PV3) (OR 2.0, 95% CI 1.1-3.6, p=0.025). Exclusive breastfeeding during the first 6 months of life was associated with a twofold higher odds of seropositivity to poliovirus serotype 3 (OR 2.0) in children who received at least 5 doses of oral polio vaccine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: