Key result
Low-flow anesthesia at 1 LPM significantly reduced the combined cost of sevoflurane and litholyme compared to 2 LPM (237.7 vs 339.6 THB/hr, p<0.001) in patients undergoing elective surgery.
Why the study?
The study aimed to compare the cost-effectiveness of low-flow (1 LPM) and medium-flow (2 LPM) anesthesia.
Does a total gas flow rate of 1 LPM reduce the cost and consumption of sevoflurane and litholyme compared to 2 LPM in patients undergoing elective surgery under general anesthesia?
RCT (n=70)
Open-label
Cluster cross-over allocation of operating rooms
No
Does a total gas flow rate of 1 LPM reduce the cost and consumption of sevoflurane and litholyme compared to 2 LPM in patients undergoing elective surgery under general anesthesia?
Absolute Event Rate: 237.7% vs 339.6%
p-value: p=<0.001
Low-flow anesthesia at 1 LPM significantly reduces the combined cost of sevoflurane and litholyme compared to 2 LPM without compromising hemodynamic stability or time to extubation.
1 LPM anesthesia cuts sevoflurane and total costs versus 2 LPM without hemodynamic or recovery differences; extends RCT support for low-flow maintenance in elective surgery.
Objective: This study aimed to compare the cost-effectiveness of low-flow (1 liter per minute (LPM)) and medium-flow (2 LPM) anesthesia. Material and Methods: Seventy patients aged 18–60 years who were undergoing elective surgery under general anesthesia were randomly allocated to receive a total gas flow rate of 1 LPM (group 1) and 2 LPM (group 2) during the maintenance of anesthesia. The primary outcome was to compare the cost and consumption of sevoflurane and litholyme. The secondary outcomes were hemodynamic stability and time to extubation. Results: The cost and consumption of sevoflurane in group 1 (197.3 Thai Bahts (THB)/hour (hr) and 9.6 milliliter (ml)/ hr) were significantly less than those in group 2 (303.2 THB/hr and 14.8 ml/hr; p-value<0.001). Although there was no difference in the cost and consumption of litholyme between the two groups, the summary cost of sevoflurane and litholyme in group 1 (237.7 THB/hr) was significantly less than that in group 2 (339.6 THB/hr; p-value<0.001). The mean arterial pressure, heart rate, and time to extubation were not significantly different in both groups. Conclusion: Patients undergoing elective surgery under general anesthesia with a total flow of 1 LPM can save on the cost of sevoflurane and litholyme, which is equivalent to 101.9 THB/hr.
No takes yet. Share an insight, caveat, or question.
Kitsiripant et al. (2022) conducted an RCT in Elective surgery under general anesthesia (n=70). Low-flow anesthesia vs. Medium-flow anesthesia (2 LPM) was evaluated on Summary cost of sevoflurane and litholyme (THB/hr) (p=<0.001). Low-flow anesthesia at 1 LPM significantly reduced the combined cost of sevoflurane and litholyme compared to 2 LPM (237.7 vs 339.6 THB/hr, p<0.001) in patients undergoing elective surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: