Key result
Intravenous glucose administration during maintenance of anesthesia did not significantly reduce the incidence of postoperative nausea and vomiting compared to placebo (10.4% vs 5.5%, p=0.360).
Why the study?
To evaluate intravenous glucose administration during anesthesia maintenance as an alternative method for diminishing postoperative nausea and vomiting in patients undergoing total abdominal hysterectomy.
Does intravenous glucose administration reduce the incidence of postoperative nausea and vomiting in patients undergoing abdominal hysterectomy under general anesthesia?
RCT (n=110)
Double-blind
Block randomization
No
Does intravenous glucose administration reduce the incidence of postoperative nausea and vomiting in patients undergoing abdominal hysterectomy under general anesthesia?
Absolute Event Rate: 10.4% vs 5.5%
p-value: p=0.360
Intravenous glucose administration during maintenance anesthesia does not significantly reduce the incidence of postoperative nausea and vomiting in women undergoing abdominal hysterectomy compared to normal saline.
Objective: This study aimed to evaluate the ability of intravenous glucose administration during the maintenance of anesthesia as an alternative method for diminishing the incidence of postoperative nausea and vomiting (PONV) in patients undergoing total abdominal hysterectomy (TAH).Material and Methods: This was a prospective, double-blind randomized placebo-controlled trial. One hundred and ten patients who were 18 - 65 years old, American Society of Anesthesiology (ASA) 1 or 2 and required general anesthesia for TAH, were divided randomly to receive 5% DNSS (Group D) or normal saline (Group N) as a maintenance fluid at a rate of 2 mL/kg/hr. The primary outcome was the incidence of PONV at the arrival time in post-anesthetic care unit (PACU). The secondary outcomes were severity of PONV, time to first dose of an antiemetic drug, amount of antiemetic dose, and length of stay in the hospital.Results: The incidence of PONV in group N was 5.5% and in group D was 10.4% (p-value = 0.360). There were no statistically significant differences regarding the VRS scores, time to the first dose of antiemetic drug, the amount of antiemetic drug, and length of hospital stay between the 2 groups.Conclusions: There was no significant difference in efficacy between intravenous glucose administration and placebo in the prevention of PONV in patients undergoing abdominal hysterectomy under general anesthesia.
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Kitsiripant et al. (2022) conducted an RCT in Postoperative nausea and vomiting (PONV) (n=110). Intravenous glucose (5% DNSS) vs. Normal saline (0.9% NSS) was evaluated on Incidence of PONV at the arrival time in post-anesthetic care unit (PACU) (p=0.360). Intravenous glucose administration during maintenance of anesthesia did not significantly reduce the incidence of postoperative nausea and vomiting compared to placebo (10.4% vs 5.5%, p=0.360).
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