Key result
Long-term hemodialysis for ≥5 years was associated with preserved cardiac performance, as 8 of 10 patients had VO2max and echocardiographic indices within the normal range.
Why the study?
Does long-term hemodialysis cause adverse effects on cardiac performance in patients treated for 5 or more years?
Observational (n=10)
Does long-term hemodialysis cause adverse effects on cardiac performance in patients treated for 5 or more years?
Long-term hemodialysis for over 5 years does not necessarily impair cardiac performance or exercise capacity in the absence of sustained hypertension.
May reassure against inevitable cardiac decline in select long-term hemodialysis patients without hypertension; hypothesis-generating and requires prospective confirmation.
To determine any adverse effects on cardiac performance resulting from long-term hemodialysis, 10 patients treated for 5 or more years (mean 8.4 years) were evaluated by exercise testing and echocardiography. Treadmill stress testing was performed to exhaustion with EKG monitoring according to the Bruce multistage protocol, while maximum oxygen consumption (VO2max) was measured directly. 1 patient had equivocal evidence for myocardial ischemia but did not experience angina. 8 of the 10 subjects had both VO2max and echocardiographic indices within the normal range established for large groups of controls. The other 2 had EKG and radiologic evidence of cardiac enlargement and had had sustained hypertension.
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Lundin et al. (2008) conducted an observational in Long-term hemodialysis (n=10). Long-term hemodialysis vs. Normal range established for large groups of controls was evaluated on VO2max and echocardiographic indices within normal range. Long-term hemodialysis for ≥5 years was associated with preserved cardiac performance, as 8 of 10 patients had VO2max and echocardiographic indices within the normal range.
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