Key result
Autoantibodies against cardiomyocyte antigens, including cytotoxic and functional types, play a significant pathogenetic role in the development of cardiac arrhythmias and sudden cardiac death.
This review highlights the emerging pathophysiological role of antimyocardial autoantibodies in arrhythmogenesis and sudden cardiac death, providing a framework for their classification based on molecular targets.
Does not support routine autoantibody testing in arrhythmia care; leaves open immunomodulatory trials in select patients.
In this review we analyze clinical and experimental studies that elucidate the prevalence of some antimyocardial autoantibodies in patients with different heart diseases and their mechanistical relevance. We propose a classification of these autoantibodies and focus on their molecular and cellular effects.
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Ryabkova et al. (2020) conducted a review in Cardiac arrhythmias and sudden cardiac death. Autoantibodies against cardiomyocyte antigens was evaluated. Autoantibodies against cardiomyocyte antigens, including cytotoxic and functional types, play a significant pathogenetic role in the development of cardiac arrhythmias and sudden cardiac death.
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