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September 30, 2003Acta Biochimica PolonicaOpen Access

Structure and functions of tumor necrosis factor-alpha converting enzyme.

Renata Mezyk Monika Bzowska Joanna Bereta

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Abstract

Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.

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Mezyk et al. (2003) studied this question.

synapsesocial.com/papers/6a75e35ed17bc701ee1629db https://doi.org/10.18388/abp.2003_3656

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