Newly Designed Amperometric Biosensor for Hydrogen Peroxide and Glucose Based on Vanadium Sulfide Nanoparticles

In the present work, we describe a facile, green, and template-free solvothermal fabrication of vanadium sulfide (VS 2 ) nanoparticles (NPs) and their application for the electrochemical detection of hydrogen peroxide (H 2 O 2 ) and glucose. The morphology and composition of as-prepared samples were well-characterized by powder X-ray diffraction, energy-dispersive spectroscopy, transmission electron microscopy, scanning electron microscopy, UV–vis spectroscopy, and Brunauer–Emmett–Teller surface area measurement. Because of their interesting electrochemical responses toward H 2 O 2, a novel nonenzymatic electrochemical sensor for H 2 O 2 and glucose detection has been proposed based on a VS 2 NP-modified glassy carbon electrode. The modified electrode showed an excellent electrochemical performance for the selective and sensitive nonenzymatic detection of H 2 O 2 in a broad concentration range of 0.5 μM to 3.0 mM, with a wide linear range of 0.5 μM to 2.5 mM and a lower detection limit of 0.224 μM. The newly developed sensor also displayed high sensitivity (41.96 μA mM –1 ) toward the detection of glucose with a broad linear range of 0.5 μM to 3 mM. The as-fabricated sensor also showed very high sensitivity, excellent reusability, long-term stability, and negligible interference ability. Moreover, the synthesized NPs were applied for H 2 O 2 and glucose detection in real samples, signifying their potential application in routine H 2 O 2 and glucose analysis. The present study reveals that as-prepared VS 2 NPs are promising for electrochemical H 2 O 2 and glucose sensing and other biological applications.