Deletion of the H240R gene in African Swine Fever Virus decreased infectious progeny virus production due to aberrant virion morphogenesis and enhanced inflammatory cytokine expression in macrophages.
The pH240R protein directs ASFV morphogenesis toward the icosahedral capsid, and its deletion enhances inflammatory cytokine expression, which may inform future vaccine or antiviral strategies.
deleted ASFV mutant (ASFV-ΔH240R). More specifically, pH240R directs the morphogenesis of ASFV toward the icosahedral capsid in the process of assembly. In addition, ASFV-ΔH240R infection induced high-level expression of inflammatory cytokines in primary porcine alveolar macrophages. Our results elucidate the role of pH240R in the process of ASFV assembly, which may instruct future research on effective vaccines or antiviral strategies.
Zhou et al. (Wed,) conducted a other in African Swine Fever Virus (ASFV) infection. Deletion of the H240R gene (ASFV-ΔH240R) was evaluated on Infectious progeny virus production, virion morphogenesis, and inflammatory cytokine expression. Deletion of the H240R gene in African Swine Fever Virus decreased infectious progeny virus production due to aberrant virion morphogenesis and enhanced inflammatory cytokine expression in macrophages.