Key result
Flecainide monotherapy successfully converted 88.2% (15 of 17) of treated fetuses with supraventricular tachycardia to sinus rhythm in a median of 3.8 days.
Why the study?
Does flecainide as first-line treatment improve conversion to sinus rhythm in fetuses with supraventricular tachycardia?
Observational (n=23)
Does flecainide as first-line treatment improve conversion to sinus rhythm in fetuses with supraventricular tachycardia?
Flecainide is an effective first-line treatment for fetal supraventricular tachycardia, achieving an 88.2% success rate for conversion to sinus rhythm.
May support flecainide monotherapy for fetal SVT; leaves open prospective validation.
OBJECTIVE: The aim of this study was to evaluate utilization, efficacy, and side effects of flecainide treatment as first-line agent in patients with fetal supraventricular tachycardia (SVT). METHOD: This retrospective review was conducted on 23 consecutive fetal tachyarrhythmia cases that met inclusion criteria. If the treatment was necessary, then flecainide was used as first-line treatment in all cases. RESULT: Among the study group, there were 21 (91.3%) cases of SVT and 2 (8.6%) cases of Atrial Flutter (AF). Sixteen fetuses had persistent SVT and five fetuses had intermittent SVT. We treated 17 fetuses with flecainide monotherapy and 15 of them converted to sinus rhythm and remaining two fetuses were refractory to monotherapy. The median time to conversion to sinus rhythm was 3.8 ± 1.6 days. Only one fetus (20%) among the intermittent SVT cases required anti-arrhythmic treatment. CONCLUSION: Our study has demonstrated that flecainide is an effective first-line treatment for fetal SVT with high success rate (88.2%), low side effect profile and relatively easy utilization. Based on the current study and recently published article results, flecainide can be recommended as the drug of first choice for treatment of fetal SVT cases.
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Ekiz et al. (2017) conducted an observational in fetal supraventricular tachycardia (SVT) (n=23). Flecainide was evaluated on Conversion to sinus rhythm. Flecainide monotherapy successfully converted 88.2% (15 of 17) of treated fetuses with supraventricular tachycardia to sinus rhythm in a median of 3.8 days.
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