What question did this study set out to answer?

To determine whether progressive weight loss in cancer cachexia is associated with changes in the size and abundance of intramyocellular lipid droplets.

May 30, 2011Journal of Cachexia Sarcopenia and MuscleOpen Access

Intramyocellular lipid droplets increase with progression of cachexia in cancer patients

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To determine whether progressive weight loss in cancer cachexia is associated with changes in the size and abundance of intramyocellular lipid droplets.
Recruited 19 cancer patients and 6 surgical controls and obtained rectus abdominis muscle biopsies during surgery.
Quantified intramyocellular lipid droplet counts and diameters using transmission electron microscopy (TEM).
Analyzed routine clinical CT scans to measure muscle area and intermuscular, visceral, and subcutaneous adipose tissue.
Cancer patients had higher lipid droplet counts (mean [SD] 6.4 [9.1] vs. 1.8 [1.9] per ×2,650 field; p = 0.036) and larger lipid droplet diameters (0.42 [0.13] vs. 0.24 [0.21] μm; p = 0.015) compared with controls.
Mean lipid droplet count correlated positively with weight loss severity (R = 0.51, p = 0.025).
Mean lipid droplet count correlated inversely with CT-measured intermuscular fat (R = -0.53, p = 0.022) and visceral fat (R = -0.51, p = 0.029).

Authors

NSNathan StephensUniversity of Worcester RSRichard J. E. SkipworthUniversity of Edinburgh AMAlisdair J. MacDonaldMott MacDonald (United Kingdom)

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Implication

Observational study reveals increased intramyocellular lipid droplet size and abundance in cancer cachexia, indicating altered muscle lipid homeostasis during progressive wasting.

Cite This Study

Stephens et al. (2011) studied this question.

synapsesocial.com/papers/6a75eaca74b63c188eb20453 https://doi.org/10.1007/s13539-011-0030-x

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Implication

Observational study reveals increased intramyocellular lipid droplet size and abundance in cancer cachexia, indicating altered muscle lipid homeostasis during progressive wasting.

Intramyocellular lipid droplets increase with progression of cachexia in cancer patients

Key Points

Discussion

Implication

Cite This Study

Intramyocellular lipid droplets increase with progression of cachexia in cancer patients

Key Points

Discussion

Implication

Cite This Study