Key result
Cardiogenic shock links to ~10-fold higher mortality during emergency CABG after failed PTCA.
Observational (n=119)
No
During a 4-year period (1986-1989), 3,502 patients had percutaneous transluminal coronary angioplasty (PTCA) in our institution. One hundred nineteen (3.4%) patients required emergency coronary artery bypass graft surgery (CABG) because of abrupt vessel closure following PTCA. Factors associated with vessel closure included lesion angulation greater than or equal to 90 degrees (p less than 0.007), the presence of thrombus (p less than 0.02), or a long (greater than or equal to 2 cm) lesion (p less than 0.03). Of these 119 emergency CABG patients, 108 (91%) arrived in the operating room in a stable condition (group I) and 11 (9%) were in cardiogenic shock (group II). Five (45%) of the group II patients were admitted to the hospital with an acute myocardial infarction and all 11 patients had a higher incidence of multivessel disease (p less than 0.05) and lower left ventricular ejection fraction (p less than 0.001) than group I patients. The overall surgical mortality was 10.1%; however, in group I the mortality was 5.6% and in group II it was 54.5% (p less than 0.001). The vessel that abruptly closed ("culprit vessel") was the left anterior descending (LAD) in 60%, the right coronary artery in 27%, and the left circumflex in 13%. The internal mammary artery was utilized to bypass the culprit artery in 51 (43%) patients, including 50% of the culprit LADs. With group I culprit LAD patients, when the left IMA was the bypass conduit, there were no hospital deaths nor strokes and there was a 6.3% incidence of perioperative infarction.
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Zapolanski et al. (1991) conducted an observational in Abrupt vessel closure following percutaneous transluminal coronary angioplasty requiring emergency CABG (n=119). Emergency CABG (including internal mammary artery graft utilization and hemodynamic status at presentation) vs. Stable condition at operating room arrival (Group I) vs. cardiogenic shock (Group II) was evaluated on Surgical mortality (p=<0.001). Emergency CABG after failed PTCA had 10.1% overall mortality (5.6% in stable patients vs 54.5% in shock, p<0.001), with 0% mortality using LIMA for stable culprit LAD closures.
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