What question did this study set out to answer?

To identify common bacterial pathogens in cases of unexplained critical illness and death using broad-range PCR.

Broad-Range Bacterial Detection and the Analysis of Unexplained Death and Critical Illness

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To identify common bacterial pathogens in cases of unexplained critical illness and death using broad-range PCR.
Examined 59 specimens from 46 cases of unexplained critical illness.
Used broad-range bacterial 16S rDNA PCR to identify pathogens.
Conducted phylogenetic analysis of amplified sequences.
Identified Neisseria meningitidis in cerebrospinal fluid from 2 meningitis cases.
Found Streptococcus pneumoniae in cerebrospinal fluid from 1 case and pleural fluid from 2 pneumonia cases.
Detected microheterogeneity of Streptococcus pneumoniae in a pleural fluid specimen, indicating multiple strains.

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Randomized trial examines causes of unexplained critical illnesses, highlighting identified pathogens in cases.

Nikkari et al. (2002) studied this question.

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