Why the study?
Does ivabradine improve outcomes compared to placebo?
Does ivabradine improve outcomes compared to placebo?
The BEAUTIFUL study evaluated the effects of the heart rate-reducing drug ivabradine compared to placebo.
Does not inform ivabradine use; leaves open efficacy versus placebo pending higher-level evidence.
So, it was with bated breath that some observers waited for the results of a new placebo controlled study – the BEAUTIFUL study – looking at the effects of ivabradine (Procorolan), an If current inhibitor of the sinus node. The only drug in its class, ivabradine is a pure heart rate reducing drug, without the effects on blood pressure and the catecholamine system found with beta blocking drugs. At present it is licensed as an anti-anginal medication. 6
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Sarah Jarvis (2008) studied this question.
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