November 1, 1983Journal of Labelled Compounds and Radiopharmaceuticals

[N‐methyl‐¹¹C]‐scopolamine: Synthesis and distribution in rat brain

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Authors

MVManhar M. VoraUniversity of Georgia RFRonald D. FinnSupélec TBThomas E. BootheLouisiana State University

Abstract

The muscarinic antagonist [N‐methyl‐ 11 C]‐scopolamine was synthesized by reductive methylation of norscopolamine with H 11 CHO and sodium cyanoborohydride, and then purified using preparative high performance liquid chromatography (HPLC). Preliminary in vivo studies in rat suggest the distribution of this compound to parallel with the muscarine receptor population in the brain.

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Vora et al. (1983) studied this question.

synapsesocial.com/papers/6a75ef41f1e99ff85ab2241e https://doi.org/10.1002/jlcr.2580201103

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[N‐methyl‐¹¹C]‐scopolamine: Synthesis and distribution in rat brain

Abstract

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[N‐methyl‐¹¹C]‐scopolamine: Synthesis and distribution in rat brain

Abstract

Discussion

Member takes

Cite This Study

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