Enantioselective Synthesis of (+)‐α‐Conhydrine and (–)‐Sedamine by L‐Proline‐Catalysed α‐Aminooxylation

An efficient organocatalytic approach to the enantioslective synthesis of two important piperidine alkaloids, namely (+)‐α‐conhydrine (98 % ee ) and (–)‐sedamine (95 % ee ), by L ‐proline‐catalysed α‐aminooxylation of aldehydes has been developed. The strategy involves an intramolecular cyclization to construct the piperidine core.