Primary Malignant Cardiac Tumors: A Rare Disease With an Adventurous Journey

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Primary malignant cardiac tumors (n=694). Intervention: Primary malignant cardiac tumor histology (sarcomas vs lymphomas) and sex. Primary outcome: Prevalence and survival of primary malignant cardiac tumors.

Q: What does this research mean for the field?

Primary malignant cardiac tumors are exceptionally rare, with a prevalence of 0.0094%, with sarcomas being the most common subtype and primary cardiac lymphomas conferring comparatively better survival outcomes. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Rajeev Gupta; Vineet Meghrajani; Rupak Desai; Neelesh Gupta

doi:10.1161/jaha.120.016032

May 10, 2020Journal of the American Heart AssociationOpen Access

Primary Malignant Cardiac Tumors: A Rare Disease With an Adventurous Journey

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Key result

Primary malignant cardiac tumors had a 0.0094% prevalence in the SEER registry (694 of 7,384,580 cases), with sarcomas being most common and lymphomas having better outcomes.

Key Points

To review the historical evolution of diagnostic imaging, clinical features, and clinical outcomes associated with primary malignant cardiac tumors.
Narrative clinical review and editorial appraisal evaluating diagnostic modalities including echocardiography, multidetector cardiac computed tomography, and cardiac magnetic resonance imaging.
Synthesis of published epidemiological series and cancer registry data evaluating patient characteristics, tumor histology, and survival.
Primary cardiac tumors have a reported prevalence between 0.0017% and 0.028%, with approximately one quarter of all primary heart and pericardial tumors identified as malignant.
Primary cardiac sarcomas are the most common primary cardiac malignancy, frequently recurring rapidly and limiting overall survival to one year following surgical resection.
Primary cardiac lymphomas exhibit a more favorable clinical course than sarcomas, with 40% of patients reported to achieve a complete response to systemic therapy.

PICO

P

Population

694 patients with primary malignant cardiac tumors identified out of 7,384,580 total cancer cases in the United States SEER registry from 1973 to 2015.

E

Exposure / Comparator

Primary malignant cardiac tumor histology (sarcomas vs lymphomas) and sex

O

Primary Outcome

Prevalence and survival of primary malignant cardiac tumors

Limitations

This is an editorial without original patient-level statistical analysis.
Lack of detailed data on specific treatments and follow-up in the referenced registry study.
Lack of information on response rates to therapy, surgical excision rates, cure rates, or recurrence rates among sarcoma and lymphoma patients.

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Implication

This article provides a historical perspective on the evolution of imaging and surgical management for primary malignant cardiac tumors.

Abstract

It is very rare or almost impossible that an event can be negative from all points of view -Dalai Lama XIV C ardiac masses and tumors have always fascinated pathologists and cardiovascular physicians/surgeons alike. Before the mid-1950s, primary cardiac tumors were usually reported at autopsies. With the development of echocardiography, the imaging and diagnosis of tumors like myxoma became a possibility. With advancements in cardiopulmonary bypass, their resection and thus a cure became an exciting reality. Further developments in imaging, particularly echocardiography, 3-dimensional echocardiography, multidetector cardiac computed tomography (MDCT), and cardiac magnetic resonance imaging (CMR), have facilitated antemortem diagnosis of cardiac tumors.

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Cite This Study

Gupta et al. (2020) conducted an editorial in Primary malignant cardiac tumors (n=694). Primary malignant cardiac tumor histology (sarcomas vs lymphomas) and sex was evaluated on Prevalence and survival of primary malignant cardiac tumors. Primary malignant cardiac tumors had a 0.0094% prevalence in the SEER registry (694 of 7,384,580 cases), with sarcomas being most common and lymphomas having better outcomes.

synapsesocial.com/papers/6a75f3198d9f8f61228b74d5 https://doi.org/10.1161/jaha.120.016032

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Primary Malignant Cardiac Tumors: A Rare Disease With an Adventurous Journey

Key Points

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Primary Malignant Cardiac Tumors: A Rare Disease With an Adventurous Journey

Key Points

PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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