Published data on skin reactions and lethal dose levels for epidermoid cancer have been analysed and mathematical factors suitable for clinical application have been derived. Based on these factors, nomograms have been constructed enabling that tumour dose, which is likely to be most effective in a given set of circumstances, to be computed. In addition, the optimal fractionation scheme, the therapeutic ratio, and the maximum permissible heterogeneity can be determined for a tumour of any specified dimensions.
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Lionel Cohen (1949) studied this question.
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