Key result
VEGF family regulates angiogenesis, lipid metabolism, and inflammation, highlighting potential therapeutic targets in atherosclerosis.
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The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved in the development of atherosclerosis and further CVDs (cardiovascular diseases). This review discusses the general regulation and functions of VEGFs, their role in lipid metabolism and atherosclerosis development and progression. These functions present the great potential of applying the VEGF family as a target in the treatment of atherosclerosis and related CVDs. In addition, we discuss several modern anti-atherosclerosis VEGFs-targeted experimental procedures, drugs and natural compounds, which could significantly improve the efficiency of atherosclerosis and related CVDs' treatment.
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Dabravolski et al. (2022) conducted a review in Atherosclerosis and related cardiovascular diseases. VEGF-targeted experimental procedures, drugs, and natural compounds was evaluated. The VEGF family regulates angiogenesis, lipid metabolism, and inflammation in atherosclerosis, presenting potential as a therapeutic target for cardiovascular diseases.
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