Skull Changes in Infants with Chronic Iron-Deficiency Anemia

THE occurrence of skull changes in association with congenital hemolytic disorders has been well known for over thirty years.1 2 3 These changes consist of widening of diploic spaces, atrophy of outer table and numerous fine striations running perpendicularly to the skull tables. Delay or lack of pneumatization of air sinuses may also be seen.4 The same x-ray picture has been described by other investigators in association with anemia of undetermined origin.5 , 6 Recently, Eng7 reported skull abnormalities such as those seen in thalassemia major in a twelve-year-old girl of Indonesian origin with chronic iron-deficiency anemia. Britton8 studied 4 similar cases. The aim . . .