Why the study?
Do antihypertensive drugs reduce systolic blood pressure proportionally to initial blood pressure in mixed normotensive and hypertensive subjects?
Population
255 mixed normotensive and hypertensive subjects
Comparison
One of five types of antihypertensive drug vs Placebo
Design
Cohort
Authors
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Initial BP may predict larger antihypertensive responses; hypothesis-generating in this cohort and requires randomized confirmation before practice implications.
Do antihypertensive drugs reduce systolic blood pressure proportionally to initial blood pressure in mixed normotensive and hypertensive subjects?
Initial systolic blood pressure is a significant predictor of the magnitude of blood pressure reduction in response to various antihypertensive therapies.
Sumner et al. (1988) studied this question.
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