The effect of the methyl and propyl esters of para‐hydroxybenzoic acid (parabens) on growth and toxin formation by C. botulinum 10755A spores was studied. Pre‐reduced anerobically sterilized media and strict anerobic techniques were employed. The addition of 200 ppm of propylparaben to a thiotone‐yeast extract‐glucose (TYG) growth medium inhibited germination and toxin production of C. botulinum 10755A for up to 120 hr at 37°C. Growth and toxin production were delayed when 100 ppm propylparaben was added to TYG. When 1200 ppm of methylparaben was added to TYG, germination and toxin production were inhibited, while 1000 ppm delayed growth and toxin production, and 400 ppm slightly delayed growth and toxin production.
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Robach et al. (1978) studied this question.
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