Why the study?
Does AST-120 reduce carotid intima-media thickness and arterial stiffness in patients with non-diabetic chronic renal failure?
Population
50 patients with non-diabetic chronic renal failure not undergoing dialysis and 30 healthy age-matched…
Comparison
AST-120 6.0 g/day for 24 months vs No AST-120 treatment
Design
RCT, randomly divided into two groups
Follow-up
24 months
Authors
Loading...
AST-120 may slow vascular progression in non-diabetic pre-dialysis CKD; extends RCT surrogate data but leaves clinical outcomes open.
Does AST-120 reduce carotid intima-media thickness and arterial stiffness in patients with non-diabetic chronic renal failure?
AST-120 may reduce arterial stiffness and carotid intima-media thickness in non-diabetic chronic renal failure patients prior to dialysis.
Nakamura et al. (2004) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: