This review highlights the complex pathogenesis of viral heart infections and emphasizes the necessity of molecular diagnostic techniques over traditional serology and histology for accurate diagnosis.
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Provides updated synthesis of viral heart infection mechanisms; leaves open translation to improved diagnostics and targeted therapies.
Viral infections of the heart cause serious clinical problems, either as infectious myocarditis, which usually is a consequence of acute infection or as idiopathic dilated cardiomyopathy, resulting rather from a chronic infection. This minireview presents an up-to-date view on pathomechanisms of viral infection of the heart tissues, the role of immune system in controlling infectious process at its various stages and current possibilities of recognizing viral infection of the heart with use of both cardiological and virological methods. Our goal was to present the variety of known viral agents causing heart infection, level of complexity in mutual virus-cell interactions, and consequent clinical scenarios.
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Kuffner et al. (2016) studied this question.
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