Both intracoronary KCN and total vessel occlusion cause abrupt impairment of myocardial contraction, though total occlusion leads to more pronounced systolic expansion at one minute.
Animal data show greater early systolic expansion with occlusion than KCN; leaves open mechanistic distinctions for human ischemia models.
Using potassium cyanide (KCN) to stimulate hypoxia, the effects of intracoronary injections of KCN were compared with total occlusions of the same vessel. Imparied contraction as measured by segment length gauges was of equally abrupt onset following both interventions. The magnitude of systolic expansion at one minute was more marked following total occlusion than after KCN administration.
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Pirzada et al. (1975) studied this question.
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