Hitherto various heterocyclic compounds have been synthesized by the reaction of ketones with ethyl cyanoacetate or ethyl acetoacetate in the presence of excessive ammonium acetate. On the basis of these facts, the reaction of malononitrile with ketones by ammonium acetate was carried out; aminopyridine derivatives, such as 2, 4-diamino-3, 5-dicyano-6-alkylpyridines (I) and 2-amino-3-cyano-4, 6-dialkylpyridines (II), were thus obtained.
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Sakurai et al. (1968) studied this question.
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